The sympathetic nervous system stimulates anti-inflammatory B cells in collagen-type II-induced arthritis

URN to cite this document:: urn:nbn:de:bvb:355-epub-361391

Pongratz, Georg ; Melzer, Madlen ; Straub, Rainer H.

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Date of publication of this fulltext: 04 Sep 2017 09:53

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Abstract

Background: As previously shown, the sympathetic nervous system (SNS) shows proinflammatory activity during initiation of arthritis but is anti-inflammatory in established collagen-induced arthritis (CIA). Interleukin 10 (IL-10)-producing B cells suppress arthritis and are a potential target of the SNS because (1) B cells express functional β2-adrenoceptors (β2ARs) and (2) IL-10, at least in ...