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IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis

URN to cite this document:
urn:nbn:de:bvb:355-epub-361666
Fuss, I. J. ; Joshi, B. ; Degheidy, H. ; Fichtner-Feigl, Stefan
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Date of publication of this fulltext: 07 Sep 2017 10:22


Abstract

Objective: Previous studies have shown that ulcerative colitis (UC) is associated with the presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating epithelial cell cytotoxicity. Here we sought to define the antigen(s) stimulating the NKT cells and to quantitate these cells in the UC lamina propria. Design: Detection of Type II NKT cells in UC lamina propria ...

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