IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-361666
DOI to cite this document:: 10.5283/epub.36166

Fuss, I. J. ; Joshi, B. ; Degheidy, H. ; Fichtner-Feigl, Stefan ; ;

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Date of publication of this fulltext: 07 Sep 2017 10:22

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Abstract

Objective Previous studies have shown that ulcerative colitis (UC) is associated with the presence of lamina propria non-invariant (Type II) NKT cells producing IL-13 and mediating epithelial cell cytotoxicity. Here we sought to define the antigen(s) stimulating the NKT cells and to quantitate these cells in the UC lamina propria. Design Detection of Type II NKT cells in UC lamina propria ...