Polymorphisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study

URN to cite this document:: urn:nbn:de:bvb:355-epub-361751
DOI to cite this document:: 10.5283/epub.36175

Derikx, M. ; Hellerbrand, Claus ; PanEuropean Working group on Alcoholic Chronic Pancreatitis, members and collaborators

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Date of publication of this fulltext: 08 Sep 2017 12:52

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Abstract

Objective: Several genetic risk factors have been identified for non-alcoholic chronic pancreatitis (NACP). A genome-wide association study reported an association of chronic pancreatitis (CP) with variants in PRSS1–PRSS2 (rs10273639; near the gene encoding cationic trypsinogen) and CLDN2–MORC4 loci (rs7057398 in RIPPLY1 and rs12688220 in MORC4). We aimed to refine these findings in a large ...