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Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

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Padrissa-Altés, S. ; Bachofner, M. ; Bogorad, R. L. ; Rossolini, T. ; Böhm, Friederike ; Liebisch, Gerhard ; Hellerbrand, Claus
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 12 Sep 2017 12:59


Objective: Fibroblast growth factors (Fgfs) are key orchestrators of development, and a role of Fgfs in tissue repair is emerging. Here we studied the consequences of inducible loss of Fgf receptor (Fgfr) 4, the major Fgf receptor (Fgfr) on hepatocytes, alone or in combination with Fgfr1 and Fgfr2, for liver regeneration after PH. Design: We used siRNA delivered via nanoparticles combined with ...


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