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Nephroprotektive Effekte der podocytären Guanylat-Cyclase A

Ströhl, Stefan (2017) Nephroprotektive Effekte der podocytären Guanylat-Cyclase A. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Sep 2017 07:23

Abstract (German)

Hintergrund: Chronisches Nierenversagen ist regelmäßig mit Albuminurie und Hypertonie vergesellschaftet. Als therapeutischer Standard kommen daher Inhibitoren des Renin-Angiotensin-Aldosteron-System wie ACE-Hemmer zum Einsatz. Eine mögliche Alternative könnten Medikamente sein, welche die Wirkung natriuretischer Peptide beeinflussen. Diese physiologischen Gegenspieler des RAAS senken u.a. den ...

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Translation of the abstract (English)

Background: Chronic renal failure is associated with albuminuria and hypertension and is usually treated with inhibitors of the renin-angiotensin-aldosterone system. Natriuretic peptides as physiological antagonists of the RAAS might represent an alternative target. NPs are known to lower blood pressure, increase renal sodium excretion and ameliorate fibrosis. However, it is unclear if these ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:2017
Referee:Prof. Dr. Frank Schweda
Date of exam:6 September 2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda
Keywords:GCA; guanylyl cyclase A; Guanylat-Cyclase A; podocyte; Podocyt; NPR-A; natriuretic peptide; kidney; Niere; cGMP; ANP; BNP
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36187
Owner only: item control page

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