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Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury

Liu, Shengwen ; Sandner, Beatrice ; Nicholson, LaShae ; Schackel, Thomas ; Tenenbaum, Liliane ; Puttagunta, Radhika ; Müller, Rainer ; Weidner, Norbert ; Blesch, Armin



Abstract

Grafting of cell-seeded alginate capillary hydrogels into a spinal cord lesion site provides an axonal bridge while physically directing regenerating axonal growth in a linear pattern. However, without an additional growth stimulus, bridging axons fail to extend into the distal host spinal cord. Here we examined whether a combinatory strategy would support regeneration of descending axons across ...

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