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Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury

Liu, Shengwen, Sandner, Beatrice, Nicholson, LaShae, Schackel, Thomas, Tenenbaum, Liliane, Puttagunta, Radhika , Müller, Rainer , Weidner, Norbert , Blesch, Armin and make_name_string expected hash reference (2017) Regulated viral BDNF delivery in combination with Schwann cells promotes axonal regeneration through capillary alginate hydrogels after spinal cord injury. Acta Biomaterialia 60, pp. 167-180.

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Abstract

Grafting of cell-seeded alginate capillary hydrogels into a spinal cord lesion site provides an axonal bridge while physically directing regenerating axonal growth in a linear pattern. However, without an additional growth stimulus, bridging axons fail to extend into the distal host spinal cord. Here we examined whether a combinatory strategy would support regeneration of descending axons across ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie
Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > PD Dr. Rainer Müller
Identification Number:
ValueType
10.1016/j.actbio.2017.07.024DOI
Keywords:CENTRAL-NERVOUS-SYSTEM; TEMPLATED AGAROSE SCAFFOLDS; FUNCTIONAL RECOVERY; GENE-EXPRESSION; ANISOTROPIC HYDROGELS; MAMMALIAN-CELLS; TISSUE-REPAIR; GROWTH; TRANSPLANTATION; GRAFTS; Alginate hydrogel; Spinal cord injury; Schwann cells; Brain-derived neurotrophic factor; Axonal regeneration; Regulated gene expression; Biomaterial; AAV5
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36191
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