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Cell-​seeded alginate hydrogel scaffolds promote directed linear axonal regeneration in the injured rat spinal cord

Guenther, Manuel Ingo ; Weidner, Norbert ; Müller, Rainer ; Blesch, Armin



Abstract

Despite recent progress in enhancing axonal growth in the injured spinal cord, the guidance of regenerating axons across an extended lesion site remains a major challenge. To det. whether regenerating axons can be guided in rostrocaudal direction, we implanted 2 mm long alginate-​based anisotropic capillary hydrogels seeded with bone marrow stromal cells (BMSCs) expressing brain-​derived ...

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