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Development and application of high-throughput screening methods to generate novel HIV-1 envelope immunogens

Graßmann, Veronika Roswitha (2018) Development and application of high-throughput screening methods to generate novel HIV-1 envelope immunogens. PhD, Universität Regensburg.

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Date of publication of this fulltext: 01 Oct 2018 05:47

Abstract (English)

HIV`s vast genetic diversity has prevented the success of common vaccine approaches. Currently, HIV-1 vaccine development focuses on the induction of broadly neutralizing antibodies (bnAbs), which target various epitopes on the trimeric envelope (Env) protein. The most potent bnAbs known today are able to neutralize more than 90 % of circulating virus strains; however, their development requires ...

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Translation of the abstract (German)

Aufgrund der enorm hohen genetischen Variabilität von HIV-1 sind konventionelle Impfstoffstrategien bislang gescheitert. Heute fokussiert sich die HIV-1 Vakzineentwicklung vor allem auf die Induktion breitneutralisierender Antikörper (bnAbs), die sich gegen verschiedene Epitope auf dem trimeren Oberflächenprotein Envelope (Env) richten. Die Besten heute bekannten bnAbs können über 90 % der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:1 October 2018
Referee:Prof. Dr. Ralf Wagner
Date of exam:23 October 2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Analysis of a mammalian cell display-based panning system for the high-throughput discovery of new AIDS vaccine candidates, Development of HIV-1 envelope immunogens with improved antigenicity and stability using a cell-based epitope mapping platform
Keywords:HIV-1 envelope, FACS, high-throughput screening, immunogen design, vaccine development
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36292
Owner only: item control page

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