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Inadequate corticosterone levels relative to arthritic inflammation are accompanied by altered mitochondria/cholesterol breakdown in adrenal cortex: a steroid-inhibiting role of IL-1β in rats

Wolff, Christine , Krinner, Katharina, Schroeder, Josef A. and Straub, Rainer H. (2015) Inadequate corticosterone levels relative to arthritic inflammation are accompanied by altered mitochondria/cholesterol breakdown in adrenal cortex: a steroid-inhibiting role of IL-1β in rats. Annals of the Rheumatic Diseases 10, pp. 1890-1897.

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Abstract

Objectives In rheumatoid arthritis, inadequate cortisol secretion was observed relative to inflammation, but reasons are unknown. Human adrenal glands cannot be investigated due to ethical reasons. Thus, a model of arthritis was studied to test inadequate glucocorticoid secretion and adrenocortical alterations. Methods Arthritis in DA rats was induced by collagen type II. Plasma hormone ...

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Item type:Article
Date:2015
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
10.1136/annrheumdis-2013-203885DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36293
Owner only: item control page

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