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Inadequate corticosterone levels relative to arthritic inflammation are accompanied by altered mitochondria/cholesterol breakdown in adrenal cortex: a steroid-inhibiting role of IL-1β in rats

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Wolff, Christine ; Krinner, Katharina ; Schroeder, Josef A. ; Straub, Rainer H.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 03 Nov 2017 09:31


Objectives In rheumatoid arthritis, inadequate cortisol secretion was observed relative to inflammation, but reasons are unknown. Human adrenal glands cannot be investigated due to ethical reasons. Thus, a model of arthritis was studied to test inadequate glucocorticoid secretion and adrenocortical alterations. Methods Arthritis in DA rats was induced by collagen type II. Plasma hormone ...


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