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Structural properties of orexins for activation of their receptors

Lang, Manja ; Bufe, Bernd ; De Pol, Silvia ; Reiser, Oliver ; Meyerhof, Wolfgang ; Beck-Sickinger, Annette G.


The closely related neuropeptides orexin A and orexin B mediate their actions, including the regulation of sleep and appetite, by the activation of the orexin 1 and 2 receptors. To elucidate the structural prerequisites for receptor activation and subtype selectivity, we performed multiple amino acid substitutions within the sequence of orexin A and human orexin B-(6-28)-peptide and analyzed ...


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