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Structural properties of orexins for activation of their receptors

Lang, Manja, Bufe, Bernd, De Pol, Silvia, Reiser, Oliver, Meyerhof, Wolfgang and Beck-Sickinger, Annette G. (2006) Structural properties of orexins for activation of their receptors. Journal of Peptide Science 12 (4), pp. 258-266.

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Other URL: http://dx.doi.org/10.1002/psc.716


The closely related neuropeptides orexin A and orexin B mediate their actions, including the regulation of sleep and appetite, by the activation of the orexin 1 and 2 receptors. To elucidate the structural prerequisites for receptor activation and subtype selectivity, we performed multiple amino acid substitutions within the sequence of orexin A and human orexin B-(6-28)-peptide and analyzed ...


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Item type:Article
Date:April 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
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Keywords:orexin • hypocretin • structure-activity relationship • CD • β-aminocyclopropane carboxylic acids
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:363
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