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New Analogs of Tariquidar: Synthesis, Characterization and Evaluation of their Inhibitory Activity against Breast Cancer Resistance Protein (ABCG2)

URN to cite this document:
urn:nbn:de:bvb:355-epub-363059
DOI to cite this document:
10.5283/epub.36305
Peña Solórzano, Diana Catherine
Date of publication of this fulltext: 06 Nov 2017 23:04


Abstract (Spanish)

El primer capítulo describe los moduladores específicos de la ABCG2 reportados hasta la fecha, La visión global puede facilitar el diseño racional de nuevos moduladores potentes y seguros. La proteína de resistencia al cáncer de mama (BCRP, ABCG2) es un miembro de la superfamilia de transportadores ATP-binding cassette (ABC) y fue descubierta recientemente. En la fisiología normal actúa como ...

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Translation of the abstract (English)

The first chapter describes the specific modulators of ABCG2 reported to date, The global vision can facilitate the rational design of new powerful and safe modulators. The breast cancer resistance protein (BCRP, ABCG2) is a member of the ATP-binding cassette (ABC) transporter superfamily and was recently discovered. In normal physiology it acts as a detoxification tool in tissue barriers, but in ...

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