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Erythropoietin-Expression in Stromazellen der Niere

Gerl, Katharina Anna-Elisabeth (2018) Erythropoietin-Expression in Stromazellen der Niere. PhD, Universität Regensburg.

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Date of publication of this fulltext: 03 Sep 2018 10:27

Abstract (German)

Erythropoietin (EPO) wird beim Erwachsenen hauptsächlich in den Nieren produziert. Hauptregulator der EPO-Gentranskription ist der Hypoxie-induzierbare Faktor 2 (HIF-2). Unter Normoxie wird die HIF-α-Untereinheit von Prolylhydroxylasen (PHDs) hydroxyliert und vom von Hippel-Lindau (Vhl) Protein erkannt, ubiquitinyliert und so dem proteasomalen Abbau zugeführt. Unter Hypoxie hingegen kann HIF-α ...

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Translation of the abstract (English)

Erythropoietin (EPO) is mainly produced in the kidneys in adults. Main regulator of the EPO gene transcription is the hypoxia inducible factor 2 (HIF-2). Under normoxic conditions the HIF-α subunit is hydroxylated by prolylhydroxylases (PHDs) and can therefore be recognized and ubiquitinated by the von Hippel-Lindau (Vhl) protein leading to its degradation. Under hypoxic conditions HIF-α ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:3 September 2018
Referee:Prof. Dr. Armin Kurtz
Date of exam:18 October 2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie
Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Keywords:Erythropoietin, renale interstitielle Fibroblasten, Erythropoietin-produzierende Zellen, HIF-2, Vhl-Deletion
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36352
Owner only: item control page

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