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Erythropoietin-Expression in Stromazellen der Niere

URN to cite this document:
urn:nbn:de:bvb:355-epub-363521
DOI to cite this document:
10.5283/epub.36352
Gerl, Katharina Anna-Elisabeth
Date of publication of this fulltext: 03 Sep 2018 10:27


Abstract (German)

Erythropoietin (EPO) wird beim Erwachsenen hauptsächlich in den Nieren produziert. Hauptregulator der EPO-Gentranskription ist der Hypoxie-induzierbare Faktor 2 (HIF-2). Unter Normoxie wird die HIF-α-Untereinheit von Prolylhydroxylasen (PHDs) hydroxyliert und vom von Hippel-Lindau (Vhl) Protein erkannt, ubiquitinyliert und so dem proteasomalen Abbau zugeführt. Unter Hypoxie hingegen kann HIF-α ...

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Translation of the abstract (English)

Erythropoietin (EPO) is mainly produced in the kidneys in adults. Main regulator of the EPO gene transcription is the hypoxia inducible factor 2 (HIF-2). Under normoxic conditions the HIF-α subunit is hydroxylated by prolylhydroxylases (PHDs) and can therefore be recognized and ubiquitinated by the von Hippel-Lindau (Vhl) protein leading to its degradation. Under hypoxic conditions HIF-α ...

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