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Regulation of gene silencing: From microRNA biogenesis to post-translational modifications of TNRC6 complexes

Danner, Johannes (2018) Regulation of gene silencing: From microRNA biogenesis to post-translational modifications of TNRC6 complexes. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 Dec 2018 06:04

Abstract (English)

‘From microRNA biogenesis to post-translational modifications of TNRC6 complexes’ summarizes the two main projects, beginning with the influence of specific RNA binding proteins on miRNA biogenesis processes. The fate of the mature miRNA is determined by the incorporation into Argonaute proteins followed by a complex formation with TNRC6 proteins as core molecules of gene silencing ...

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Translation of the abstract (German)

"From microRNA biogenesis to post-translational modifications of TNRC6 complexes" fasst die beiden Hauptprojekte dieser Doktorarbeit zusammen. miRNAs werden als primäre transkripte (pri-miRNA) von der RNA Polymerase II transkribiert. Die weitere Verarbeitung erfolgt durch den Mikroprozessor-Komplex, der das katalytisch aktive Enzym Drosha enthält, welches die pri-miRNA zu Vorläufer-miRNAs ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:6 December 2018
Referee:Prof. Dr. Gunter Meister
Date of exam:6 December 2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Keywords:TNRC6, Phosphorylierung, Ago, Herpes Viren TNRC6, Phosphorylation, Ago, Herpes Viruses
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36399
Owner only: item control page

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