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Complement Components Showed a Time-Dependent Local Expression Pattern in Constant and Acute White Light-Induced Photoreceptor Damage

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Schäfer, Nicole ; Grosche, Antje ; Schmitt, Sabrina I. ; Braunger, Barbara M. ; Pauly, Diana
Date of publication of this fulltext: 04 Dec 2017 15:57


Background: Photoreceptor cell death due to extensive light exposure and induced oxidative-stress are associated with retinal degeneration. A correlated dysregulation of the complement system amplifies the damaging effects, but the local and time-dependent progression of this mechanism is not thoroughly understood. Methods: Light-induced photoreceptor damage (LD) was induced in Balb/c mice with ...


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