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Complement Components Showed a Time-Dependent Local Expression Pattern in Constant and Acute White Light-Induced Photoreceptor Damage

Schäfer, Nicole, Grosche, Antje, Schmitt, Sabrina I., Braunger, Barbara M. and Pauly, Diana (2017) Complement Components Showed a Time-Dependent Local Expression Pattern in Constant and Acute White Light-Induced Photoreceptor Damage. Frontiers in Molecular Neuroscience 10 (197), pp. 1-17.

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Date of publication of this fulltext: 04 Dec 2017 15:57

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Other URL: http://doi.org/10.3389/fnmol.2017.00197, https://www.frontiersin.org/articles/10.3389/fnmol.2017.00197/full

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Background: Photoreceptor cell death due to extensive light exposure and induced oxidative-stress are associated with retinal degeneration. A correlated dysregulation of the complement system amplifies the damaging effects, but the local and time-dependent progression of this mechanism is not thoroughly understood. Methods: Light-induced photoreceptor damage (LD) was induced in Balb/c mice with ...

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Item type:Article
Date:20 June 2017
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Medicine > Lehrstuhl für Humangenetik
Biology, Preclinical Medicine > Institut für Anatomie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fnmol.2017.00197DOI
Keywords:INDUCED RETINAL DEGENERATION; MACULAR DEGENERATION; MOUSE RETINA; OXIDATIVE STRESS; GENE-EXPRESSION; CELL-DEATH; ACTIVATION; MECHANISMS; RISK; SUSCEPTIBILITY; light-induced photoreceptor degeneration; complement system; retina; RPE/choroid; C3
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36409
Owner only: item control page

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