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Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation

Starick, Lisa, Riano, Felipe, Karunakaran, Mohindar M., Kunzmann, Volker, Li, Jianqiang, Kreiss, Matthias, Amslinger, Sabine , Scotet, Emmanuel, Olive, Daniel, De Libero, Gennaro and Herrmann, Thomas (2017) Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates Vγ9Vδ2 TCR clonotypes and interferes with phosphoantigen activation. European Journal of Immunology 47 (6), pp. 982-992.

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Other URL: http://doi.org/10.1002/eji.201646818


Abstract

Phosphoantigens (PAgs)-like HMBPP ((E)-4-hydroxy-3-methyl-but-2-enyl diphosphate) and butyrophilin 3 (BTN3A, CD277)-specific monoclonal antibody 20.1 induce TCR-mediated activation of Vγ9Vδ2 T cells. Here, we compared murine reporter cells transduced with Vγ9Vδ2 TCRs G115, D1C55, and MOP for the activation in culture with human RAJI cells and PAgs or mAb 20.1 and its single-chain (sc) derivative. ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1002/eji.201646818DOI
Keywords:Butyrophilin; Human γδ T cells; Phosphoantigen; T-cell activation; T-cell receptor
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36436
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