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Transcriptional regulation by the oncoprotein STAT5: role of acetylation and deacetylation processes

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Pinz, Sophia Charlotte
Date of publication of this fulltext: 14 Dec 2017 09:15

Abstract (English)

Activated signal transducer and activator of transcription STAT5 induces the expression of genes essential for cell differentiation, proliferation and inhibition of apoptosis. Previous work from our group demonstrated that the deacetylase inhibitor trichostatin A (TSA) attenuates transcriptional activation of STAT5 target genes at a step following STAT5 binding to its DNA binding sites by ...


Translation of the abstract (German)

Der Transkriptionsfaktor STAT5 (signal transducer and activator of transcription 5) induziert nach seiner Aktivierung die Expression essenzieller Gene für Zelldifferenzierung, Proliferation und Hemmung der Apoptose. Frühere Arbeiten unserer Gruppe zeigten, dass der Deacetylaseinhibitor Trichostatin A (TSA) die transkriptionelle Aktivierung von STAT5 Zielgenen an einem Schritt hemmt, welcher auf ...


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