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In vivo analysis of the mitochondrial protein frataxin in Drosophila melanogaster

Edenharter, Oliver Manfred (2018) In vivo analysis of the mitochondrial protein frataxin in Drosophila melanogaster. PhD, Universität Regensburg.

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Date of publication of this fulltext: 02 Jul 2018 08:25

Abstract (English)

Friedreich’s ataxia is the most common recessive ataxia in the Caucasian population. It is caused by a defect in the expression of the mitochondrial protein frataxin and leads to neurodegeneration. The main role of frataxin lies in iron-sulphur cluster biosynthesis and loss of the protein results in mitochondrial iron accumulation and diminished energy production within the cell. Although ...


Translation of the abstract (German)

Die Friedreich-Ataxie ist die häufigste rezessive Ataxie bei Weißen. Sie wird durch einen Defekt in der Expression des mitochondriellen Proteins Frataxin hervorgerufen und führt zu Neurodegeneration. Die Hauptrolle von Frataxin liegt in der Biogenese von Eisen-Schwefel-Clustern, wobei der Verlust des Proteins zu Eisenakkumulation in Mitochondrien und verringerter Energieproduktion führt. Obwohl ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:2 July 2018
Referee:Prof. Dr. Stephan Schneuwly
Date of exam:13 December 2017
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Keywords:Friedreich’s ataxia, Drosophila melanogaster, mitofusin, er stress, glia, mitophagy, Muscles, MtRosella
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36479
Owner only: item control page


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