Go to content
UR Home

Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity

She, Xueke, Pegoli, Andrea, Mayr, Judith, Hübner, Harald, Bernhardt, Günther , Gmeiner, Peter and Keller, Max (2017) Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased M2R Affinity and Selectivity. ACS Omega 2 (10), pp. 6741-6754.

[img]
Preview
License: Creative Commons Attribution 4.0
PDF - Submitted Version
Download (2MB)
Date of publication of this fulltext: 19 Jan 2018 11:46

at publisher (via DOI)

Other URL: http://doi.org/10.1021/acsomega.7b01085, http://pubs.acs.org/doi/full/10.1021/acsomega.7b01085

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

In search for selective ligands for the muscarinic acetylcholine receptor (MR) subtype M-2, the dimeric ligand approach, that is combining two pharmacophores in one and the same molecule, was pursued. Different types (agonists, antagonists, orthosteric, and allosteric) of monomeric MR ligands were combined by various linkers with a dibenzodia-zepinone-type MR antagonist, affording five types of ...

plus


Export bibliographical data



Item type:Article
Date:16 October 2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1021/acsomega.7b01085DOI
Keywords:PROTEIN-COUPLED RECEPTORS; ALLOSTERIC BINDING-SITES; BITOPIC LIGANDS; RESIDENCE TIME; HIGHLY POTENT; M-2 RECEPTOR; ANTAGONIST; AGONISTS; MODULATORS; DESIGN;
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36538
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons