Effect of iodinated contrast media on renal perfusion: A randomized comparison study in pigs using quantitative contrast-enhanced ultrasound (CEUS)

URN to cite this document:

urn:nbn:de:bvb:355-epub-365492 Copy

DOI to cite this document:

10.5283/epub.36549 Copy

Lamby, Philipp ; Jung, Friedrich ; Graf, Stefanie ; Schellenberg, Lotte ; Falter, Johannes ; Platz Batista da Silva, Natascha ; Schreml, Stephan ; Prantl, Lukas ; Franke, Ralf P. ; Jung, Ernst M.

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Date of publication of this fulltext: 22 Jan 2018 12:12

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Details

Item type:	Article
Journal or Publication Title:	Scientific Reports
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
Volume:	7
Number of Issue or Book Chapter:	1
Page Range:	pp. 1-10
Date:	13 October 2017
Institutions:	Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie
Projects:	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.1038/s41598-017-13253-y DOI
Keywords:	ACUTE KIDNEY INJURY; HUMAN ERYTHROCYTES; MICROCIRCULATION; MORPHOLOGY; DISEASE; OSMOLAR; ULTRASONOGRAPHY; DIFFERENTIATION; INTRAARTERIAL; MORTALITY;
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	36549

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Abstract

The administration of iodinated contrast media (CM) can cause microcirculatory disorder leading to acute renal dysfunction. In a prospective, randomized investigation two CM (Iodixanol vs Iopromide) were compared in 16 pigs. Each animal received 10 intra-aortal injections (5 ml Iodixanol or 4.32 ml Iopromide). Microcirculation was assessed using contrast-enhanced ultrasound (CEUS) directly on the ...

Abstract

The administration of iodinated contrast media (CM) can cause microcirculatory disorder leading to acute renal dysfunction. In a prospective, randomized investigation two CM (Iodixanol vs Iopromide) were compared in 16 pigs. Each animal received 10 intra-aortal injections (5 ml Iodixanol or 4.32 ml Iopromide). Microcirculation was assessed using contrast-enhanced ultrasound (CEUS) directly on the kidney surface using time-to-peak (TTP) and blood-volume-analysis. Macroscopic observations were documented. Post mortem residual CM distribution in the kidneys was detected using X-ray. TTP was significantly prolonged over the descending vasa recta of the Iopromide group. This coincided with a visible marble-like pattern on the kidney surface occurring in 30 out of 80 Iopromide-injections but in 4 out of 80 Iodixanol-injections (p = 0.007). The blood volume over the entire kidney did not change after Iodixanol-application, but decreased by about 6.1% after Iopromide-application. The regional blood volume in the renal cortex showed a tendency to decrease by about 13.5% (p = 0.094) after Iodixanol-application, and clearly decreased by about 31.7% (p = 0.022) after Iopromide-application. The study revealed a consistent influence of repeated injections of two different CM on the kidney perfusion using three different imaging methods (CEUS analysis, macroscopic observation and X-ray analysis).

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Metadata last modified: 25 Feb 2021 07:48

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