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Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways

Weiss, Thomas S. , Lupke, Madeleine, Ibrahim, Sara, Buechler, Christa, Lorenz, Julia, Ruemmele, Petra, Hofmann, Ute , Melter, Michael and Dayoub, Rania (2017) Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways. PLOS ONE 12 (9), e0184282.

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Date of publication of this fulltext: 23 Jan 2018 10:16

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Other URL: http://doi.org/10.1371/journal.pone.0184282, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184282

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Free fatty acids (FFA) induce steatosis and lipo-toxicity and correlate with severity of NAFLD. In this study we aimed to investigate the role of exogenous and endogenous ALR (augmenter of liver regeneration) for FFA induced ER (endoplasmatic reticulum) - stress ...

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Item type:Article
Date:6 September 2017
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0184282DOI
Keywords:MITOCHONDRIAL INTERMEMBRANE SPACE; ENDOPLASMIC-RETICULUM STRESS; INDUCED OBESE MICE; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; SULFHYDRYL OXIDASE; LIPIDOMIC ANALYSIS; METABOLIC DISEASE; FATTY; HEPATOPOIETIN;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36555
Owner only: item control page

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