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Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

Schäfer, Nicole, Grosche, Antje, Reinders, Joerg, Hauck, Stefanie M., Pouw, Richard B., Kuijpers, Taco W., Wouters, Diana, Ehrenstein, Boris, Enzmann, Volker, Zipfel, Peter F., Skerka, Christine and Pauly, Diana (2016) Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases. Frontiers in Immunology 7 (542), pp. 1-16.

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Date of publication of this fulltext: 25 Jan 2018 12:50

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Other URL: http://doi.org/10.3389/fimmu.2016.00542, https://www.frontiersin.org/articles/10.3389/fimmu.2016.00542/full


Abstract

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of atypical hemolytic-uremic syndrome (aHUS), while also found to be protective in age-related macular degeneration (AMD). The precise function of FHR-3 remains to be fully characterized. We generated four mouse ...

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Item type:Article
Date:28 November 2016
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fimmu.2016.00542DOI
Keywords:FHR-3/CFHR3, specific antibody, rheumatic disease, microglia/macrophage, FH competition, immune therapy, retinal degeneration
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36585
Owner only: item control page

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