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Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

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Schäfer, Nicole ; Grosche, Antje ; Reinders, Joerg ; Hauck, Stefanie M. ; Pouw, Richard B. ; Kuijpers, Taco W. ; Wouters, Diana ; Ehrenstein, Boris ; Enzmann, Volker ; Zipfel, Peter F. ; Skerka, Christine ; Pauly, Diana
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 25 Jan 2018 12:50


The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of atypical hemolytic-uremic syndrome (aHUS), while also found to be protective in age-related macular degeneration (AMD). The precise function of FHR-3 remains to be fully characterized. We generated four mouse ...


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