Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases

URN to cite this document:: urn:nbn:de:bvb:355-epub-365851
DOI to cite this document:: 10.5283/epub.36585

Schäfer, Nicole ; Grosche, Antje

; Reinders, Joerg ; Hauck, Stefanie M.

; Pouw, Richard B.

; Kuijpers, Taco W. ; Wouters, Diana ; Ehrenstein, Boris ; Enzmann, Volker ; Zipfel, Peter F. ; Skerka, Christine ; Pauly, Diana

Preview

License: Creative Commons Attribution 4.0
PDF - Published Version
(3MB)

Date of publication of this fulltext: 25 Jan 2018 12:50

Alternative links to fulltext:DOI Publisher Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of atypical hemolytic-uremic syndrome (aHUS), while also found to be protective in age-related macular degeneration (AMD). The precise function of FHR-3 remains to be fully characterized. We generated four mouse ...