Renal allograft rejection, lymphocyte infiltration, and de novo donor-specific antibodies in a novel model of non-adherence to immunosuppressive therapy

URN to cite this document:: urn:nbn:de:bvb:355-epub-366423
DOI to cite this document:: 10.5283/epub.36642

Kühne, Louisa ; Jung, Bettina ; Poth, Helen ; Schuster, Antonia ; Wurm, Simone ; Ruemmele, Petra ; Banas, Bernhard ; Bergler, Tobias

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Date of publication of this fulltext: 29 Jan 2018 17:52

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Abstract

Background: Non-adherence has been associated with reduced graft survival. The aim of this study was to investigate the immunological mechanisms underlying chronic renal allograft rejection using a model of non-adherence to immunosuppressive therapy. We used a MHC (major histocompatibility complex) -mismatched rat model of renal transplantation (Brown Norway to Lewis), in which rats received ...