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Evidence for cooperative Na+ and Cl- binding by strongly hydrated L-​proline

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Dmitrieva, Olga A. ; Fedotova, Marina V. ; Buchner, Richard
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 01 Mar 2018 09:35


In Nature, L-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect, knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielec. spectroscopy and found that Pro remains strongly hydrated up to high amino acid ...


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