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Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Schatz, Valentin, Neubert, Patrick, Rieger, Franz and Jantsch, Jonathan (2018) Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses. Frontiers in Immunology 9 (216), pp. 1-8.

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Date of publication of this fulltext: 27 Mar 2018 13:47

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Other URL: http://doi.org/10.3389/fimmu.2018.00216


Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.

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Item type:Article
Date:22 February 2018
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Projects:Open Access Publizieren (DFG)
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Keywords:hypoxia-inducible factor 1, leishmaniasis, macrophages, oxygen, Nos2, hypoxia
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36941
Owner only: item control page


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