Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7

URN to cite this document:: urn:nbn:de:bvb:355-epub-558282
DOI to cite this document:: 10.5283/epub.36975

Pannem, Rajeswara R. ; Dorn, Christoph

; Hellerbrand, Claus ; Massoumi, Ramin

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Date of publication of this fulltext: 06 Apr 2018 06:42

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Abstract

Hepatic fibrosis is considered as a physiological wound‐healing response to liver injury. The process involves several factors, such as hepatocyte growth factor (HGF), which restrains hepatic injury and facilitates reversibility of fibrotic reaction in response to an acute insult. Chronic liver injury and sustained inflammation cause progressive fibrosis and, ultimately, organ dysfunction. The ...