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Conformational Transitions of the Ras Protein Involved in Macromolecular Interactions and Modulated by Small Compounds. A Biophysical Approach Using NMR and X-Ray Crystallography at Ambient and High Pressures

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Lopes, Pedro
Date of publication of this fulltext: 26 Mar 2019 06:52

Abstract (English)

The guanine binding nucleotide protein Ras is a small GTPase that controls central regulatory processes such as cell differentiation, proliferation and apoptosis by alternating between an active, GTP-bound, and an inactive, GDP-bound state. Both, the intrinsic hydrolysis of GTP and the exchange reaction from GDP to GTP are very slow. Two classes of regulatory proteins called GAP’s and GEF’s are ...


Translation of the abstract (German)

Das Guaninnukleotid-bindende Ras Protein ist eine kleine GTPase, die durch den Wechsel zwischen dem aktiven, GTP-gebundenen Zustand und dem inaktiven, GDP-gebundenen Zustand verschiedene regulatorische Prozesse in der Zelle kontrolliert, wie z.B. Zelldifferenzierung, Zellproliferation und Apoptose. Sowohl die intrinsische Hydrolyse von GTP als auch die Austauschreaktion von GDP zu GTP sind sehr ...


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