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Elevated systemic monocyte chemoattractrant protein-1 in hepatic steatosis without significant hepatic inflammation

Kirovski, Georgi ; Dorn, Christoph ; Huber, Hanna ; Moleda, Lukas ; Niessen, Catrin ; Wobser, Hella ; Schacherer, Doris ; Buechler, Christa ; Wiest, Reiner ; Hellerbrand, Claus



Abstract

Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and the metabolic syndrome. It encompasses a clinico-pathologic spectrum of conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). The latter develops upon pro-inflammatory cell infiltration and is widely considered as the first relevant pathophysiological step in NAFLD-progression. The ...

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