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Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells

Wobser, Hella ; Dorn, Christoph ; Weiss, Thomas S. ; Amann, Thomas ; Bollheimer, Cornelius ; Büttner, Roland ; Schölmerich, Jürgen ; Hellerbrand, Claus


Despite the initial belief that non-alcoholic fatty liver disease is a benign disorder, it is now recognized that fibrosis progression occurs in a significant number of patients. Furthermore, hepatic steatosis has been identified as a risk factor for the progression of hepatic fibrosis in a wide range of other liver diseases. Here, we established an in vitro model to study the effect of hepatic ...


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