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Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

Gäbele, Erwin ; Mühlbauer, Marcus ; Dorn, Christoph ; Weiss, Thomas S. ; Froh, Matthias ; Schnabl, Bernd ; Wiest, Reiner ; Schölmerich, Jürgen ; Obermeier, Florian ; Hellerbrand, Claus


Accumulating evidence indicates that bacteria and bacterial products promote hepatic fibrogenesis. The activation of hepatic stellate cells (HSC) plays a central role in hepatic fibrosis. Here, we demonstrate that HSC express toll-like receptor 9 (TLR9), a pattern recognition receptor that is activated by CpG motifs present specifically in bacterial DNA. Upon CpG stimulation human as well as ...


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