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SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure

Mustroph, Julian (2018) SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure. PhD, Universität Regensburg.

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Date of publication of this fulltext: 11 Apr 2018 10:58

Other URL: http://www.jmmc-online.com/article/S0022-2828(18)30036-1/fulltext


Abstract (English)

Aims: Ethanol has acute negative inotropic and arrhythmogenic effects. The underlying mechanisms, however, are largely unknown. Sarcoplasmic reticulum Ca2+-leak is an important mechanism for reduced contractility and arrhythmias. Ca2+-leak can be induced by oxidative stress and Ca2+/Calmodulin-dependent protein kinase II (CaMKII). Therefore, we investigated the influence of acute ethanol exposure ...

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Translation of the abstract (German)

Im Rahmen dieser Promotion wurde die toxische Wirkung von Ethanol auf die elektromechanische Kopplung der Herzmuskelzelle untersucht. Schlüsselbefunde waren ein erhöhtes diastolisches sarkoplasmatisches Kalziumleck unter Ethanol und eine kontraktile Dysfunktion. Ihm NADPH -Oxidase II knock out Modell und in der CaMKII-redox-dead-Maus (CaMKII MMVV transgen) waren diese Effekte nicht zu beobachten, ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:11 April 2018
Referee:Prof. Dr. Lars S. Maier
Date of exam:10 April 2018
Institutions:UNSPECIFIED
Keywords:CaMKII, ethanol, arrhythmias, Ca leak, Ca sparks
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37058
Owner only: item control page

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