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Effects of L-Glutamate on auditory afferent activity in view of its proposed excitatory transmitter role in the mammalian cochlea

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Gleich, Otto ; Johnstone, Brian M. ; Robertson, Donald
Date of publication of this fulltext: 05 Aug 2009 13:43


This report describes the effects of L-glutamate (Glu) introduced into the perilymph of scala tympani on the spontaneous and tone-evoked activity of guinea pig single primary auditory afferents. Concentrations below 2 mmol/1 were in general ineffective, while a concentration of 5 mmol/1 caused a marked decrease of the neural activity. At 2 mmol/1, roughly 60% of the Glu-perfusions were effective ...


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