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Leukocyte-reduced platelet-rich plasma stimulates the in vitro proliferation of adipose-tissue derived mesenchymal stem cells depending on PDGF signaling.

Lang, Siegmund (2018) Leukocyte-reduced platelet-rich plasma stimulates the in vitro proliferation of adipose-tissue derived mesenchymal stem cells depending on PDGF signaling. PhD, Universität Regensburg.

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Date of publication of this fulltext: 30 Apr 2018 13:38

at PubMed

Other URL: https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch170246


Abstract (English)

BACKGROUND Platelet-rich Plasma (PRP) is suggested as xenoprotein-free cell-culture medium replacement for animalderived supplements. OBJECTIVE The aim of this study was to investigate PRP-triggered signaling in adipose derived mesenchymal stem cells (ASCs). Leukocyte- reduced PRP might be an alternative to bovine standard culture media additives. METHODS PRP was obtained from 4 male patients. We ...

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Translation of the abstract (German)

Hintergrund PRP wird in der aktuellen Literatur als ein xenoprotein-freier Zusatz für Zellkulturmedium in Modellen mit mesenchymalen Stammzellen (MSCs) zur Stimulation der Proliferation vorgeschlagen. Hypothese Leukozyten-reduziertes PRP erhöht die Proliferation von humanen mesenchymalen Stammzellen aus Fettgewebe (hASCs) abhängig von der Inkubationszeit und angewandten Dosierung über die PDGF ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:30 April 2018
Referee:PD Dr. Markus Loibl
Date of exam:23 April 2018
Institutions:Medicine > Lehrstuhl für Unfallchirurgie
Identification Number:
ValueType
28922143PubMed ID
Keywords:Platelet-rich Plasma (PRP); human adipose-tissue derived mesenchymal stem cells; cell culture; in vitro proliferation; protein expression; c-MYC; PDGF signaling; PDGF receptor beta.
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37179
Owner only: item control page

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