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Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Zimara, Nicole, Chanyalew, Menberework, Aseffa, Abraham, van Zandbergen, Ger, Lepenies, Bernd, Schmid, Maximilian, Weiss, Richard, Rascle, Anne, Wege, Anja Kathrin, Jantsch, Jonathan, Schatz, Valentin, Brown, Gordon D. and Ritter, Uwe (2018) Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development. Frontiers in Immunology 9 (263), pp. 1-20.

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Date of publication of this fulltext: 09 May 2018 11:15

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Other URL: http://doi.org/10.3389/fimmu.2018.00263


Abstract

Resistant mouse strains mount a protective T cell-mediated immune response upon infection with Leishmania (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-γ production, while susceptibility is associated with an IL-4-dependent Th2-type response. It has been shown that dermal dendritic cells are crucial for inducing protective ...

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Item type:Article
Date:26 February 2018
Institutions:Medicine > Lehrstuhl für Immunologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fimmu.2018.00263DOI
Keywords:Curdlan, β-glucan, Dectin-1, cutaneous leishmaniasis, adaptive immunity, dendritic cells, T helper 1 and T helper 2 cells
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37293
Owner only: item control page

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