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Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

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Zimara, Nicole ; Chanyalew, Menberework ; Aseffa, Abraham ; van Zandbergen, Ger ; Lepenies, Bernd ; Schmid, Maximilian ; Weiss, Richard ; Rascle, Anne ; Wege, Anja Kathrin ; Jantsch, Jonathan ; Schatz, Valentin ; Brown, Gordon D. ; Ritter, Uwe
Date of publication of this fulltext: 09 May 2018 11:15


Resistant mouse strains mount a protective T cell-mediated immune response upon infection with Leishmania (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-gamma production, while susceptibility is associated with an IL-4-dependent Th2-type response. It has been shown that dermal dendritic cells are crucial for inducing protective ...


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