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Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia

Edenharter, Oliver, Schneuwly, Stephan and Navarro, Juan A. (2018) Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia. Frontiers in Molecular Neuroscience 11 (38), pp. 1-25.

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Date of publication of this fulltext: 09 May 2018 11:22

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Other URL: http://doi.org/10.3389/fnmol.2018.00038


Abstract

Friedreich’s ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin. Despite its pivotal effect on biosynthesis of iron-sulfur clusters and mitochondrial energy production, little is known about the influence of frataxin depletion on homeostasis of the cellular mitochondrial network. We have carried out a ...

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Item type:Article
Date:6 March 2018
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fnmol.2018.00038DOI
Dewey Decimal Classification:500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37294
Owner only: item control page

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