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Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia

URN to cite this document:
urn:nbn:de:bvb:355-epub-372946
DOI to cite this document:
10.5283/epub.37294
Edenharter, Oliver ; Schneuwly, Stephan ; Navarro, Juan A.
Date of publication of this fulltext: 09 May 2018 11:22



Abstract

Friedreich's ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin. Despite its pivotal effect on biosynthesis of iron-sulfur clusters and mitochondrial energy production, little is known about the influence of frataxin depletion on homeostasis of the cellular mitochondrial network. We have carried out a ...

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