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Functional characterization of HMGN5 in
chromatin architecture and gene expression

URN to cite this document:
urn:nbn:de:bvb:355-epub-373121
Araya Fuenzalida, Ingrid Carolina
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License: Creative Commons Attribution No Derivatives 4.0
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Date of publication of this fulltext: 07 Jan 2019 08:26


Abstract (English)

The modulation of higher order structure of chromatin has profound implications in the regulation of nuclear processes, like transcription, replication, recombination or DNA repair. Those processes require accessible DNA to recruit large protein complexes to function. In humans, the architectural proteins of the “high mobility group nucleosomal binding domain” (HMGN) family participate in the ...

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Translation of the abstract (German)

Wir präsentieren hier die funktionelle Charakterisierung von HMGN5 in Hinblick auf die Regulierung der Chromatinstruktur und Genexpression. Wir haben herausgefunden, daß HMGN5 eine duale Rolle in der Regulation der Genexpression übernimmt, indem es zum einen direkt regulatorische Regionen in Chromatin bindet und zum anderen wachsende RNA-Transkripte bindet.


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