Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists

URN to cite this document:: urn:nbn:de:bvb:355-epub-373145
DOI to cite this document:: 10.5283/epub.37314

Pockes, Steffen

; Wifling, David

; Keller, Max ; Buschauer, Armin

; Elz, Sigurd

Preview

PDF
(7MB)

Date of publication of this fulltext: 14 May 2018 13:57

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

On the basis of the long-known prototypic pharmacophore 3-(1H-imidazol-4-yl) propylguanidine (SK&F 91486, 2), monomeric, homodimeric, and heterodimeric bisalkylguanidine-type histamine H-2 receptor (H2R) agonists with various alkyl spacers were synthesized. Aiming at increased H2R selectivity of the ligands, the imidazol-4-yl moiety was replaced by imidazol-1-yl, 2-aminothiazol-5-yl or ...