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Highly Potent, Stable, and Selective Dimeric Hetarylpropylguanidine-Type Histamine H2 Receptor Agonists

URN to cite this document:
urn:nbn:de:bvb:355-epub-373145
DOI to cite this document:
10.5283/epub.37314
Pockes, Steffen ; Wifling, David ; Keller, Max ; Buschauer, Armin ; Elz, Sigurd
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Date of publication of this fulltext: 14 May 2018 13:57


Abstract

On the basis of the long-known prototypic pharmacophore 3-(1H-imidazol-4-yl)propylguanidine (SK&F 91486, 2), monomeric, homodimeric, and heterodimeric bisalkylguanidine-type histamine H2 receptor (H2R) agonists with various alkyl spacers were synthesized. Aiming at increased H2R selectivity of the ligands, the imidazol-4-yl moiety was replaced by imidazol-1-yl, 2-aminothiazol-5-yl or ...

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