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Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

URN to cite this document:
urn:nbn:de:bvb:355-epub-374350
DOI to cite this document:
10.5283/epub.37435
Niedermair, Tanja ; Schirner, Stephan ; Seebröker, Raphael ; Straub, Rainer H. ; Grässel, Susanne
Date of publication of this fulltext: 29 Jun 2018 08:41



Abstract

Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies we observed impaired biomechanical and structural bone parameters in tachykinin (Tac) 1-deficient mice lacking SP. Here, we aim to specify effects of SP on metabolic parameters of bone ...

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