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Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

Niedermair, Tanja, Schirner, Stephan, Seebröker, Raphael, Straub, Rainer H. and Grässel, Susanne (2018) Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts. Scientific Reports 8 (9199), pp. 1-15.

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Date of publication of this fulltext: 29 Jun 2018 08:41

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Other URL: http://doi.org/10.1038/s41598-018-27432-y, https://www.nature.com/articles/s41598-018-27432-y


Abstract

Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies we observed impaired biomechanical and structural bone parameters in tachykinin (Tac) 1-deficient mice lacking SP. Here, we aim to specify effects of SP on metabolic parameters of bone ...

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Item type:Article
Date:15 June 2018
Institutions:Medicine > Lehrstuhl für Orthopädie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41598-018-27432-yDOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37435
Owner only: item control page

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