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Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts

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Niedermair, Tanja ; Schirner, Stephan ; Seebröker, Raphael ; Straub, Rainer H. ; Grässel, Susanne
Date of publication of this fulltext: 29 Jun 2018 08:41


Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies we observed impaired biomechanical and structural bone parameters in tachykinin (Tac) 1-deficient mice lacking SP. Here, we aim to specify effects of SP on metabolic parameters of bone ...


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