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Impact of Hydroxyglutarate on Dendritic Cell Activation

URN to cite this document:
urn:nbn:de:bvb:355-epub-374959
Cardenas-Conejo, Zugey Elizabeth
Date of publication of this fulltext: 19 Jun 2019 04:49


Abstract (English)

Tumor development is commonly associated with genetic alterations such as activation of oncogenes or the silencing of tumor suppressor genes. Recently point mutations in genes encoding isocitrate dehydrogenase (IDH) have gained substantial interest in glioma classification. IDH mutations are also frequently found in neoplasias including acute myeloid leukemia (AML). Mutated IDH aquires the ...

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Translation of the abstract (German)

Tumoren werden durch Mutationen in Protoonkogenen und Tumorsurpressorgenen verursacht. Diese Mutationen führen entweder zur Aktivierung von Onkogenen oder zum Stilllegen von Tumorsupressorgenen. Aktuell wurden Punktmutationen im Gen der Isocitrat-Dehydrogenase (IDH) für die Klassifizierung von Gliomen beschrieben. IDH Mutationen werden neben dem Gliom, häufig in der Akuten myeloischen Leukämie ...

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