Prevalence of hepatitis E virus infection in pediatric solid organ transplant recipients - A single-center experience

DOI to cite this document:

10.5283/epub.37521 Copy

Hoerning, André ; Hegen, Bianca ; Wingen, Anne-Margret ; Cetiner, Metin ; Lainka, Elke ; Kathemann, Simone ; Fiedler, Melanie ; Timm, Jörg ; Wenzel, Jürgen J. ; Hoyer, Peter F. ; Gerner, Patrick

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Date of publication of this fulltext: 08 Aug 2018 14:14

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Details

Item type:	Article
Journal or Publication Title:	Pediatric Transplantation
Publisher:	Wiley
Volume:	16
Number of Issue or Book Chapter:	7
Page Range:	pp. 742-747
Date:	2012
Institutions:	Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:	Value Type 10.1111/j.1399-3046.2012.01740.x DOI
Keywords:	hepatitis E Virus – renal transplantation – liver transplantation
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	37521

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Abstract

HEV infection appears to be an emerging disease in industrialized countries. The aim of this study was to evaluate the prevalence of HEV infection in pediatric solid organ transplant recipients. One hundred and twenty‐four pediatric recipients of liver (n = 41) or kidney (n = 83) transplants aged between one and 18 yr were screened for anti‐HEV IgG antibodies. Patients were tested for fecal HEV ...

Abstract

HEV infection appears to be an emerging disease in industrialized countries. The aim of this study was to evaluate the prevalence of HEV infection in pediatric solid organ transplant recipients. One hundred and twenty‐four pediatric recipients of liver (n = 41) or kidney (n = 83) transplants aged between one and 18 yr were screened for anti‐HEV IgG antibodies. Patients were tested for fecal HEV RNA excretion if they showed anti‐HEV seropositivity. As a control group, 108 immunocompetent pediatric patients without liver disease aged between three and 18 yr were screened for anti‐HEV IgG. HEV seroprevalence was 2.4% in renal Tx (2/83), 4.9% in liver Tx patients (2/41), and 3.2% overall (4/124). Three of these four patients were HEV RNA‐negative. In one renal transplant patient, HEV genotype 3 RNA excretion persisted and liver enzymes were elevated, indicating chronic hepatitis. In the control group, eight patients (7.4%) were HEV IgG‐positive without biochemical evidence of hepatitis. The prevalence of HEV infection in pediatric renal or liver transplant recipients is not higher compared with immunocompetent children. Chronic HEV infection with long‐term carriage of the virus may develop in pediatric transplant recipients. Autochthonous HEV infection needs to be considered in uncertain cases of hepatitis in immunosuppressed as well as immunocompetent children.

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Metadata last modified: 25 Nov 2020 19:29

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