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Enhanced Replication of Hepatitis E Virus Strain 47832c in an A549-Derived Subclonal Cell Line

URN to cite this document:
urn:nbn:de:bvb:355-epub-375291
DOI to cite this document:
10.5283/epub.37529
Schemmerer, Mathias ; Apelt, Silke ; Trojnar, Eva ; Ulrich, Rainer G ; Wenzel, Jürgen J. ; Johne, Reimar
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License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 02 Aug 2018 07:43


Abstract

Hepatitis E virus (HEV) is a human pathogen with increasing importance. The lack of efficient cell culture systems hampers systematic studies on its replication cycle, virus neutralization and inactivation. Here, several cell lines were inoculated with the HEV genotype 3c strain 47832c, previously isolated from a chronically infected transplant patient. At 14 days after inoculation the highest ...

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