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Real-Time Imaging Reveals Augmentation of Glutamate-Induced Ca2+ Transients by the NO-cGMP Pathway in Cerebellar Granule Neurons

Paolillo, Michael , Peters, Stefanie, Schramm, Andrea, Schlossmann, Jens and Feil, Robert (2018) Real-Time Imaging Reveals Augmentation of Glutamate-Induced Ca2+ Transients by the NO-cGMP Pathway in Cerebellar Granule Neurons. International Journal of Molecular Sciences 19, p. 2185.

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Date of publication of this fulltext: 28 Aug 2018 09:13

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Abstract

Dysfunctions of NO-cGMP signaling have been implicated in various neurological disorders. We have studied the potential crosstalk of cGMP and Ca2+ signaling in cerebellar granule neurons (CGNs) by simultaneous real-time imaging of these second messengers in living cells. The NO donor DEA/NO evoked cGMP signals in the granule cell layer of acute cerebellar slices from transgenic mice expressing a ...

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Item type:Article
Date:2018
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.3390/ijms19082185DOI
Keywords:cyclic GMP; calcium; nitric oxide; guanylyl cyclase; cerebellar granule cells; protein kinase; PKG; FRET imaging; transgenic mice
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37613
Owner only: item control page

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