Real-Time Imaging Reveals Augmentation of Glutamate-Induced Ca2+ Transients by the NO-cGMP Pathway in Cerebellar Granule Neurons

URN to cite this document:: urn:nbn:de:bvb:355-epub-376139
DOI to cite this document:: 10.5283/epub.37613

Paolillo, Michael

; Peters, Stefanie ; Schramm, Andrea ; Schlossmann, Jens

; Feil, Robert

License: Creative Commons Attribution 4.0
PDF - Published Version
(3MB)

Date of publication of this fulltext: 28 Aug 2018 09:13

Alternative links to fulltext:DOI

Details

Preview

Indexed in

Export bibliographical data

Abstract

Dysfunctions of NO-cGMP signaling have been implicated in various neurological disorders. We have studied the potential crosstalk of cGMP and Ca2+ signaling in cerebellar granule neurons (CGNs) by simultaneous real-time imaging of these second messengers in living cells. The NO donor DEA/NO evoked cGMP signals in the granule cell layer of acute cerebellar slices from transgenic mice expressing a ...