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Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis

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Guoxing, Liu ; Guilai, Liu ; Hong, Chen ; Borst, Oliver ; Gawaz, Meinrad ; Vortkamp, Andrea ; Schreiber, Rainer ; Kunzelmann, Karl ; Lang, Florian
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Date of publication of this fulltext: 28 Aug 2018 09:24


Background/Aims: The ubiquitously expressed Ca2+ Activated Cl- Channel Ano6 participates in the stimulation of cell membrane scrambling. Defective Ano6 underlies the Scott syndrome, an inherited bleeding disorder with impaired scrambling of plasma membrane phospholipids. At least in theory, the bleeding disorder of Scott syndrome may result from impaired platelet function. Activators of platelets ...


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