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Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis

Guoxing, Liu, Guilai, Liu, Hong, Chen, Borst, Oliver, Gawaz, Meinrad, Vortkamp, Andrea, Schreiber, Rainer , Kunzelmann, Karl and Lang, Florian (2015) Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis. Cellular Physiology and Biochemistry 37 (5), pp. 1934-1944.

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Date of publication of this fulltext: 28 Aug 2018 09:24

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Abstract

Background/Aims: The ubiquitously expressed Ca2+ Activated Cl- Channel Ano6 participates in the stimulation of cell membrane scrambling. Defective Ano6 underlies the Scott syndrome, an inherited bleeding disorder with impaired scrambling of plasma membrane phospholipids. At least in theory, the bleeding disorder of Scott syndrome may result from impaired platelet function. Activators of platelets ...

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Item type:Article
Date:20 November 2015
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann
Identification Number:
ValueType
10.1159/000438554DOI
Keywords:Cytosolic Ca2+ concentration, Phosphatidylserine translocation, P-selectinIntegrin, Cell volume
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37636
Owner only: item control page

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