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Downregulation of Checkpoint Protein Kinase 2 in the Urothelium of Healthy Male Tobacco Smokers

Breyer, Johannes, Denzinger, Stefan, Hartmann, Arndt and Otto, Wolfgang (2016) Downregulation of Checkpoint Protein Kinase 2 in the Urothelium of Healthy Male Tobacco Smokers. Urologia Internationalis 97 (4), pp. 480-481.

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Date of publication of this fulltext: 28 Aug 2018 13:49

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Other URL: https://www.karger.com/Article/FullText/446827


Abstract

With this letter to the editor we present for the first time a study on CHEK2 expression in normal urothelium of healthy male smokers, former smokers and non-smokers. We could show a statistically significant downregulation of this DNA repair gene in current smokers compared to non-smokers, suggesting that smoking downregulates CHEK2 in normal urothelium, probably associated with an early step in carcinogenesis of urothelial bladder carcinoma.


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Item type:Article
Date:2 June 2016
Institutions:Medicine > Lehrstuhl für Urologie
Identification Number:
ValueType
10.1159/000446827DOI
Keywords:Bladder, Bladder carcinoma, Immunohistochemistry, Transurethral resection, EtiologyRisk factor, CHEK2
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37638
Owner only: item control page

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