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The Microphthalmia-Associated Transcription Factor p.E318K Mutation Does Not Play a Major Role in Sporadic Renal Cell Tumors from Caucasian Patients

Stoehr, Christine G., Walter, Bernhard, Denzinger, Stefan, Ghiorzo, Paola, Sturm, Richard A., Hinze, Raoul, Moch, Holger, Junker, Kerstin, Hartmann, Arndt and Stoehr, Robert (2016) The Microphthalmia-Associated Transcription Factor p.E318K Mutation Does Not Play a Major Role in Sporadic Renal Cell Tumors from Caucasian Patients. Pathobiology 83 (4), pp. 165-169.

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Date of publication of this fulltext: 28 Aug 2018 14:24

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Abstract

Objective: The transcription factor MITF (microphthalmia-associated transcription factor) is known to induce expression of hypoxia-inducible factor (HIF1-α), which is involved in renal carcinogenesis. The MITF p.E318K mutation leads to deficient SUMOylation of MITF, resulting in enhanced activation of its target genes. A case-control study on melanoma patients who coincidentally were affected by ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Urologie
Identification Number:
ValueType
10.1159/000443311DOI
Keywords:Microphthalmia-associated transcription factor, Mutation, Renal cell carcinoma, Pyrosequencing
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37644
Owner only: item control page

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