Galectin-3 Modulates Experimental Colitis

URN to cite this document:: urn:nbn:de:bvb:355-epub-376579
DOI to cite this document:: 10.5283/epub.37657

Lippert, Elisabeth ; Stieber-Gunckel, Manuela ; Dunger, Nadja ; Falk, Werner ; Obermeier, Florian ; Kunst, Claudia

License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 28 Aug 2018 12:46

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Abstract

Background: We recently identified galectin-3 (gal-3) as a new and strong fibroblast activator produced by colonic epithelial cells. Very little is known about the influence of gal-3 in inflammatory bowel disease. We, therefore, investigated the impact of gal-3 on dextran sodium sulfate (DSS)-induced colitis in a mouse model. Methods: Colonic lamina propria fibroblasts of healthy controls were ...