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11β-Hydroxysteroid Dehydrogenase Enzymes Modulate Effects of Glucocorticoids in Rheumatoid Arthritis Synovial Cells

Schmidt, Martin and Straub, Rainer H. (2015) 11β-Hydroxysteroid Dehydrogenase Enzymes Modulate Effects of Glucocorticoids in Rheumatoid Arthritis Synovial Cells. Neuroimmunomodulation 22 (1-2), pp. 40-45.

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Date of publication of this fulltext: 28 Aug 2018 13:42

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Other URL: https://www.karger.com/Article/FullText/362725


Abstract

The tissue availability of active glucocorticoids (cortisol in humans) depends on their rate of synthesis from cholesterol, downstream metabolism, excretion and interconversion. The latter is mediated by the 11β-hydroxysteroid dehydrogenases (11βHSDs). In this review, we summarize the features of the two isoenzymes, 11βHSD1 and 11βHSD2, and current available experimental data related to 11βHSDs, ...

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Item type:Article
Date:2015
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.1159/000362725DOI
Keywords:Rheumatoid arthritis, Glucocorticoid receptor, 11β-Hydroxysteroid dehydrogenases
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37662
Owner only: item control page

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