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11β-Hydroxysteroid Dehydrogenase Enzymes Modulate Effects of Glucocorticoids in Rheumatoid Arthritis Synovial Cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-376621
DOI to cite this document:
10.5283/epub.37662
Schmidt, Martin ; Straub, Rainer H.
[img]License: Allianz- bzw. Nationallizenz
PDF - Published Version
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Date of publication of this fulltext: 28 Aug 2018 13:42



Abstract

The tissue availability of active glucocorticoids (cortisol in humans) depends on their rate of synthesis from cholesterol, downstream metabolism, excretion and interconversion. The latter is mediated by the 11β-hydroxysteroid dehydrogenases (11βHSDs). In this review, we summarize the features of the two isoenzymes, 11βHSD1 and 11βHSD2, and current available experimental data related to 11βHSDs, ...

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