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Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis

URN to cite this document:
urn:nbn:de:bvb:355-epub-376771
DOI to cite this document:
10.5283/epub.37677
Wirth, Anna M. ; Khomenko, Andrei ; Baldaranov, Dobri ; Kobor, Ines ; Hsam, Ohnmar ; Grimm, Thomas ; Johannesen, Siw ; Bruun, Tim-Henrik ; Schulte-Mattler, Wilhelm ; Greenlee, Mark W. ; Bogdahn, Ulrich
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
(1MB)
Date of publication of this fulltext: 30 Aug 2018 13:07



Abstract

Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process affecting upper and lower motor neurons as well as non-motor systems. In this study, precentral and postcentral cortical thinning detected by structural magnetic resonance imaging (MRI) were combined with clinical (ALS-specific functional rating scale revised, ALSFRS-R) and neurophysiological (motor unit ...

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