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Eco-friendly one pot synthesis of caffeic acid phenethyl ester (CAPE) via an in situ created deep eutectic solvent

Fischer, Veronika ; Touraud, Didier ; Kunz, Werner



Abstract

In this paper, a new strategy towards the synthesis of caffeic acid phenethyl ester (CAPE) is introduced. The reaction is carried out in a deep eutectic solvent made of caffeic acid and choline chloride. Caffeic acid is used as part of the solvent and as reactant. Phenethyl alcohol is soluble in this mixture in every molar ratio, and as a consequence no additional solvent is necessary. Reaction ...

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