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Murine DX5+NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4+CD62Lhigh T Cells through Fas Ligand

Werner, Jens Martin, Damian, Michael, Frakas, Stefan A., Schlitt, Hans J. , Geissler, Edward K. and Hornung, Matthias (2018) Murine DX5+NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4+CD62Lhigh T Cells through Fas Ligand. Journal of Immunology Research 2018, pp. 1-8.

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Date of publication of this fulltext: 07 Nov 2018 13:21

at publisher (via DOI)

Other URL: https://www.hindawi.com/journals/jir/2018/8175810/


Abstract

Introduction. It has been previously shown that immunoregulatory DX5+NKT cells are able to prevent colitis induced by CD4+CD62Lhigh T lymphocytes in a SCID mouse model. The aim of this study was to further investigate the underlying mechanism in vitro. Methods. CD4+CD62Lhigh and DX5+NKT cells from the spleen of Balb/c mice were isolated first by MACS, followed by FACS sorting and cocultured for ...

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Item type:Article
Date:30 September 2018
Institutions:Medicine > Lehrstuhl für Chirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1155/2018/8175810DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37751
Owner only: item control page

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