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Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions

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Schulze, Markus ; Hutterer, Maria ; Sabo, Anja ; Hoja, Sabine ; Lorenz, Julia ; Rothhammer-Hampl, Tanja ; Herold-Mende, Christel ; Floßbach, Lucia ; Monoranu, Camelia ; Riemenschneider, Markus J.
Date of publication of this fulltext: 28 Sep 2018 05:58


Background: The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin binding protein cofilin, and pyridoxal 5'-phosphate, the active form of vitamin B6. Phosphoregulation of cofilin, among other functions, plays an important role in cell migration, ...


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