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Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions

Schulze, Markus, Hutterer, Maria, Sabo, Anja, Hoja, Sabine, Lorenz, Julia, Rothhammer-Hampl, Tanja, Herold-Mende, Christel, Floßbach, Lucia, Monoranu, Camelia and Riemenschneider, Markus J. (2018) Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions. BMC Cancer 18 (524), pp. 1-15.

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Date of publication of this fulltext: 28 Sep 2018 05:58

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Other URL: http://doi.org/10.1186/s12885-018-4440-4


Abstract

Background The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin binding protein cofilin, and pyridoxal 5′-phosphate, the active form of vitamin B6. Phosphoregulation of cofilin, among other functions, plays an important role in cell migration, ...

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Item type:Article
Date:3 May 2018
Institutions:Medicine > Abteilung für Neuropathologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12885-018-4440-4DOI
Keywords:Chronophin, Cofilin, Vitamin metabolism, Glioma
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37797
Owner only: item control page

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